#HIERARCHICAL SEQUENTIAL TESTING TRIAL#

The keyword 'CHANGE' in the /STATISTICS subcommand is the request for a test of the change in R squared. If you're running Regression through a syntax window, the blocks are built by a series of /METHOD = ENTER subcommands, as in: The predictor list across blocks is cumulative.

Note that you don't need to enter the block 1 variables in block 2 or later blocks. The problem of simultaneous sequential tests for noninferiority and superiority of a treatment, as compared to an active control, is considered in terms of continuous hierarchical families of one-sided null hypotheses, in the framework of group sequential and adaptive two-stage designs. This will request a test of the significance of the change in R squared at each successive block in the model. In the Statistics dialog, check R squared change. You don't need to click 'Next' after entering the variable(s) for the last block.Ĭlick the 'Statistics' button in the main Linear Regression dialog box. If there is a third block, click the 'Next' button again to clear the second block variables from the box and enter the 3rd block variable(s).Ĭontinue this sequence for as many blocks as needed. This clears that box.Įnter the variable(s) for block 2 in your model. objsa sequence or mapping of Series or DataFrame objects. Then click the 'Next' button at the top of the 'Independent(s)' box. Can also add a layer of hierarchical indexing on the concatenation axis, which may be useful if.

#HIERARCHICAL SEQUENTIAL TESTING TRIAL#

If you are using the menus and dialog boxes in SPSS, you can run a hierarchical regression by entering the predictors in a set of blocks with Method = Enter, as follows:Įnter the predictor(s) for the first block into the 'Independent(s)' box in the main Linear Regression dialog box. Hierarchical testing of multiple endpoints in group-sequential trials Ekkehard Glimm, Willi Maurer, Frank Bretz Statistics in Medicine 2010 January 30, 29 (2): 219-28 We consider the situation of testing hierarchically a (key) secondary endpoint in a group-sequential clinical trial that is mainly driven by a primary endpoint. Yes, this analysis is very feasible in SPSS REGRESSION.

Hierarchical sequential testing